Medical Biochemistry by John Baynes and Marek 4th Ed

Medical Biochemistry – Brought to you in a thorough yet accessible manner, the new edition of Medical Biochemistry gives access to all of the latest information on basic and clinically focused genetic and molecular biology.

Featuring a team of contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this updated medical textbook offers a unique combination of both research and practice that’s ideal for today’s problem-based integrated courses.

Preface – Medical Biochemistry

We now present the 4th edition of Medical Biochemistry. Our aim remains, as before, to provide biochemical foundation for the study of clinical medicine – with down-to-earth practical relevance.

A textbook is a snapshot of a field as it exists at the time of writing. Such ‘photographic’ metaphor is appropriate here,because biochemistry undergoes constant change; in the period since the publication of the 3rd edition it has probably changed faster than ever before.While core metabolic pathways remain largely unchanged,our understanding of underlying regulatory mechanisms is better, thanks to the progress in identifying signaling path-ways. In many instances, these pathways have become tar-gets for drugs, and underpin the impressive therapeutic progress in fields such as oncology.Since completion of the Human Genome Project, genome-wide association studies and bioinformatic analyses have allowed us to put together a new picture of genetic regulation, the hallmarks of which are interactions between multiple, heterogeneous transcription factors and gene pro-moters, and the emerging field of epigenetics. Medical Biochemistry

Behind this are, as had happened many times before in the history of science, major advances in methodology, including rapidly expanding genetic screening. The common denominator between methodologies now employed in genetic research laboratories and hospital clinical labs has been the advent of robotics and bioinformatics, and therefore the ability to process – and interpret – an ever-increasing amount of data.This edition has again been substantially updated. We have rewritten the chapters on lipids, glucose homeostasis, nutrition and biochemical endocrinology, and added a section on the effects of exercise on muscle development and cardiovascular health.

The chapter on the omics incorporates new directions in proteomics, metabolomics and recombinant DNA technology.This edition also benefits from the expertise of new authors who have shared their perspectives on signaling, fat and glycoconjugate metabolism, exercise biochemistry, nutrition,and blood coagulation processes.We have expanded the chapter on the GI tract as an important interface between the organism and the environment,and now have a separate short chapter on kidney function. Medical Biochemistry

In both we provide more information on membrane transport systems. We remain convinced that the biochemistry of water and electrolyte balance is as important for future clinicians as the key metabolic pathways – and deserve more emphasis in the biochemistry curricula.We have updated literature and web references throughout the textbook.

At the same time we were able to eliminate some web links in this edition, because search engines and websites such as Wikipedia and YouTube now provide quick access to so many rapidly evolving resources.Throughout the text we strive to explain complex issues as simply as possible, but try hard not to become superficial.

Unfortunately, new fields come with new terminologies and numerous additions to scientific slang. The discovery of new genes and new signaling pathways means new names and acronyms. We identify them here not as material to be committed to memory, but to help build a knowledge framework without oversimplification. The fact that some chapters may seem complex to the uninitiated may also reflect the true state of knowledge – the complexity, or even a touch of confusion, often present before a coherent picture emerges. The Question Bank (Self-Assessment) and many more resources are available at the Elsevier website,www.student-consult.com, to which the reader is referred. Student Consult also provides links to other Elsevier biomedical textbooks which integrate and build on knowledge of medical bio-chemistry. Medical Biochemistry

There is also a companion publication, Medical Biochemistry Flash Cards, which provides means for quick revision. As before, we welcome comments, criticisms and suggestions from our readers. Many of these suggestions are incorporated in this 4th edition. There is no better way to continue the improvement of this text.

Key Features – Medical Biochemistry

Relate biochemistry to everyday practice with the help of Clinical Boxes integrated into the text, and access in-depth coverage of important topics – including recent research in biochemistry – through Advanced Concept Boxes.

Test your knowledge and improve retention withActive Learning Boxes at the conclusion of each chapter, and quickly review the most common lab tests performed with convenient Clinical Test Boxes.

Effectively study the most updated information in biochemistry with the help of a dynamic, full-color design.Better understand the relationship between science and clinical practice with material organized by organ rather than system.

Table of Contents – Medical Biochemistry

01 Introduction

02 Amino Acids and Proteins

03 Carbohydrates and Lipids

04 Blood and Plasma Proteins

05 Oxygen Transport

06 Catalytic Proteins-Enzymes

07 Hemostasis and Thrombosis

08 Membranes and Transport

09 Bioenergetics and Oxidative Metabolism

10 Digestion and Absorption of Nutrients: The Gastrointestinal Tract

11 Vitamins and Minerals

12 Anaerobic Metabolism of Glucose in the Red Blood Cell

13 Carbohydrate Storage and Synthesis in Liver and Muscle

14 The Tricarboxylic Acid Cycle – Medical Biochemistry

15 Oxidative Metabolism of Lipids in Liver and Muscle

16 Biosynthesis and Storage of Fatty Acids

17 Biosynthesis of Cholesterol and Steroids

18 Lipoproteins Metabolism and Atherogenesis

19 Biosynthesis and Degradation of Amino Acids

20 Muscle: Energy Metabolism and Contraction

21 Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus

22 Nutrition and Energy Balance

23 Role of Kidneys in Metabolism

24 Water and Electrolyte Homeostasis

25 Regulation of Hydrogen Ion Concentration (Acid-Base Balance)

26 Bone Metabolism and Calcium Homeostasis

27 Complex Carbohydrates: Glycoproteins

28 Complex Lipids – Medical Biochemistry

29 The Extracellular Matrix

30 Role of the Liver in Metabolism

31 Biosynthesis and Degradation of Nucleotides

32 Deoxyribonucleic Acid

33 Ribonucleic Acid

34 Protein Synthesis and Turnover

35 Regulation of Gene Expression: Basic Mechanisms

36 Regulation of Gene Expression: Genomics, Proteomics and Metabolomics

37 Oxygen and Life – Medical Biochemistry

38 The Immune Response

39 Biochemical Endocrinology

40 Membrane Receptors and Signal Transduction

41.1 Neurotransmitters

41.2 Neurochemistry

42 Cellular Homeostasis: Cell Growth and Cancer

43 Aging

Details – Medical Biochemistry

No. of pages: 658Language: EnglishCopyright: © Saunders 2015Published: 8th February 2014Imprint: SaunderseBook ISBN: 9780702062506eBook ISBN: 9780323313636eBook ISBN: 9780702062483eBook ISBN: 9781455745814

About the Author – Medical Biochemistry

John Baynes

Affiliations and Expertise

Carolina Distinguished Professor Emeritus; Department of Pharmacology, Physiology and Neuroscience; University of South Carolina School of Medicine; Columbia, South Carolina; USA

Marek Dominiczak

Affiliations and Expertise – Medical Biochemistry

Honorary Professor of Clinical Biochemistry and Medical Humanities, University of Glasgow; Consultant Biochemist, NHS Greater Glasgow and Clyde,Glasgow, UK