Lifespan by David Sinclair Pdf

Lifespan by David Sinclair Pdf

Download Lifespan by David Sinclair pdf book free online. In Lifespan, one of the world’s foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn’t immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the front lines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs – many from Dr. David Sinclair’s own lab – that demonstrate how we can slow down, or even reversethe genetic clock. The key is activating newly discovered vitality genes – the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes – such as intermittent fasting, cold exposure, and exercising with the right intensity – that have been shown to help lead to longer lives. GET FREE AUDIOBOOK

Summary of Lifespan by David Sinclair Pdf

It is a book that will alter the way you think about life, death, and aging. The central argument of Sinclair’s book is that aging is an illness. This contradicts popular belief that aging is an unavoidable part of life. When you think about aging as a sickness, you open up a whole new universe of possibilities: diseases may be prevented, treated, cured, and even eradicated. Because many diseases (such as cancer) are caused by aging, eliminating aging could remove entire categories of downstream disorders. Even better, a cure for aging would provide the enticing benefit of longer healthspans (vitality and quality of life) in addition to longer lifespans—the latter would be useless without the former.

Lifespan is a layman’s guide to science written by a recognized professor. Sinclair’s credentials are impeccable: he is a professor of molecular genetics at Harvard Medical School and a top aging expert. His research labs have produced groundbreaking findings as well as a regular stream of students who have gone on to conduct even more cutting-edge research. The book’s claims may be excessively ambitious, but the science behind them is sound, if not definitive. As a result, One of the most thrilling books I’ve read in quite some time.

Sinclair’s optimism is based on a concept known as “the informational theory of aging.” It’s a concept that could be the key to curing the aging process. This theory, which has received a lot of scientific support in the last 30 years, claims that aging is caused by a loss of information, specifically epigenetic information (non-DNA encoded information). Sinclair compares the loss of information to that of a DVD. A DVD’s surface becomes scratched and degraded over time. These scratches hide the underlying data and cause playback issues. What’s needed is a technique to polish the disc and restore or replace any missing data on a regular basis.

Fortunately, a variety of biological systems and cellular pathways are capable of performing this critical “polishing” and repair. Sinclair’s own research has long been focused on the sirtuans family of enzymes (SIR2). Sirtuans are necessary for DNA repair (essential to maintaining health and vitality). The introduction of more sirtuans into test subjects resulted in surprising metabolic and physiological alterations, as well as longer lifespans, in trials with yeast, fruit flies, and mice. While additional research is needed, the current findings are encouraging: by repairing damaged information, one can delay or even reverse the aging process.

The book is split into three sections: past, present, and future. In Part I, we learn about Magna superstes, a hypothetical ancient life-form that evolved “the survival circuit,” a highly precise and beneficial genetic characteristic that increased cellular reproduction and DNA repair. Modern humans have inherited this survival circuit, which may be seen in the aforementioned sirtuans (along with other pathways like AMPK, mTOR, and others). Part II explains the many ways we can support, activate, and magnify this survival circuit, using the scientific underpinnings from Part I. Diet and exercise are really important. The benefits of calorie restriction and intermittent fasting are underlined in particular (well substantiated in the scientific literature). There are also a variety of chemicals that can activate or magnify the effects of sirtuans and other DNA repair pathways, including organic substances, medicines, and nutritional supplements. Part III explores the ethical and long-term consequences of future breakthroughs and therapies. What economic, political, environmental, and social consequences would a population with a median age of 150 have? Will longevity technology benefit everyone, or just the wealthy? Will living longer make climate change worse? Any new technology has implications, as well as legitimate complaints. It is in our best interests to think about these issues, as well as potential solutions, early and regularly.

To say I was blown away with Lifespan is an understatement. I’m a sucker for concepts that give me fresh perspectives on the world and make me question long-held beliefs. This book is exactly what I mean when I say “mental pivot.” I’m not sure if the “informational theory of aging” is the key to longevity or merely a stepping stone to a better future theory (either way, we’re on the right track). More research, time, and inquiry, the author readily admits, are required. Nonetheless, it’s fascinating to see human creativity and curiosity working together to find answers to these fundamental issues. You can complete a book and barely think about it, or you can finish a book and can’t stop thinking about it. Lifespan belongs to the latter group.

Pros: It’s difficult to stop thinking about the concepts in this densely packed tome. A fantastic mix of practical ideas and out-of-the-box thinking. Combining a prominent scientist with a professional writer and illustrator results in fascinating and accessible explanations of complex concepts. This is edge-of-your-seat scientific reading.

Cons: Some acronym and jargon-soup paragraphs will make your head spin. Fortunately, the writers use vivid analogies, lucid explanations, and helpful examples and diagrams to counterbalance this. It’s also worth mentioning that the scientific world has chastised Sinclair for being unduly hopeful about the ramifications of his longevity study.

About the Author

Professor of genetics at Harvard Medical School, David Sinclair, PhD, AO He has been identified by Time magazine as “one of the 100 most influential persons in the world” and “one of the top fifty most influential individuals in healthcare.” He is a member of the American Federation for Aging Research’s board of directors, and he has received over 35 honors for his research and key scientific accomplishments. Dr. Sinclair has appeared on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among other programs. With his wife and three children, he enjoys hiking and kayaking in Boston.

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