Download Clinical Biochemistry Lecture Notes 9th Edition

Clinical Biochemistry Lecture Notes 9th Edition pdf

Clinical Biochemistry Lecture Notes presents the fundamental science behind common biochemical investigations used in clinical practice. Taking a system-based approach, it explores the underlying physiological rationale for tests, with each test explained within the context of disruption by disease.

It also explores the value and limitations of biochemical investigations, while helping readers to quickly develop the knowledge and skills required to select the appropriate investigations for diagnosis and management, and to correctly interpret test results. Case studies throughout chapters place the information within a clinical context to further assist readers in the development of test-selection and interpretation skills.

Key features include:

  • A comprehensive, yet concise overview of the science behind common biochemical investigations
  • Helps readers rapidly acquire a fully integrated, practical understanding of biochemical diagnostics
  • Full-colour flowcharts and algorithms detailing the rationale for tests, the biochemical processes involved, and test procedures, for quick comprehension and reference
  • More clinical cases demonstrating application to practice

Now in its 9th edition, this classic introductory, reference, and revision text is indispensable to medical students, and all those who want to quickly acquire a practical understanding of the scientific principles underpinning biochemical tests and a working knowledge of test selection, test procedures, and the interpretation of results within a clinical context. 

Contents – Clinical Biochemistry Lecture Notes

Preface, vi
List of abbreviations, vii
How to use your textbook, x
About the companion website, xiii
1 Requesting and interpreting tests, 1
2 Disturbances of water, sodium and potassium balance, 13
3 Acid–base balance and oxygen transport, 30
4 Renal disease, 43
5 Disorders of calcium, phosphate and magnesium metabolism, 60
6 Diabetes mellitus and hypoglycaemia, 76
7 Disorders of the hypothalamus and pituitary, 89
8 Abnormalities of thyroid function, 102
9 Disorders of the adrenal cortex and medulla, 116
10 Investigation of gonadal function infertility, menstrual irregularities and hirsutism, 134
11 Pregnancy and antenatal screening, 152
12 Cardiovascular disorders, 160
13 Liver disease, 174
14 Gastrointestinal tract disease, 188
15 Nutrition, 198
16 Trauma, infl ammation, immunity and malignancy, 213
17 Disorders of iron and porphyrin metabolism, 228
18 Uric acid, gout and purine metabolism, 238
19 Central nervous system and cerebrospinal fl uid, 245
20 Therapeutic drug monitoring and chemical toxicology, 249
21 Clinical biochemistry in paediatrics and the elderly, 261
Index, 278

REVIEWS – Clinical Biochemistry Lecture Notes

The advantages of this title are that after the first few chapters which cover the basics of Clinical Biochemistry such as ‘Requesting and Interpreting tests’ and basic acid-base biochemistry, the rest of the text is dedicated to system disorders. From the first chapter of the book, this is a highly patient orientated title with 4 cases in the first chapter on the basics of tests putting what is said into a clinical context. The rest of the chapters are really useful if you want to get your head around specific conditions such as ‘Jaundice’ and how they are caused at a biochemistry level or you wish to revise the acid-base balance and how this relates to blood gasses.
The disadvantages of this title are that I would have liked to have seen summaries of the key points at the end of each chapter within the print, though this is not essential as should you wish them, they are in part included in the online extras which have both questions & a few notes available for you to utilise.
In conclusion if you are in the first few years of medical school then I would hazard to say that this is one of the best titles available covering clinical biochemistry as unlike many others that I have read in this area & reviewed, it is not padded out with detail that you would not be expected to know at medical school and includes many useful case examples. I would strongly encourage a medical student to see whether this title is in their university library if they don’t want to purchase it straight away or look at the online resources which are freely available for the title to see whether it suites your style. (Medical Student, Lancaster University)


Th is is the ninth edition of the book that fi rst appeared under the authorship of Professor Gordon Whitby, Dr Alistair Smith and Professor Iain Percy-Robb in 1975. Changes to the medical teaching curriculum and pressures on teaching time have reduced or even abolished teaching courses that focus exclusively on clinical biochemistry. Instead, the discipline is integrated into systems-based teaching at all levels of the medical curriculum. Whilst this has many advantages in placing the material in a holistic, clinical context it is also very valuable to bring together teaching material on clinical biochemistry. Clinical Biochemistry Lecture Notes

This textbook attempts to do that. In one volume can be found a wealth of information on the biochemical basis of many diseases, the selection of biochemical diagnostic tests and their interpretation. To that end, the book is highly relevant to the medical student throughout the whole training period and as a reference for the qualifi ed doctor. Moreover, other health professionals, such as nurses who take on specialist roles in defi ned clinical areas, should also fi nd the book helpful. In addition, we believe it would be of value to specialist registrars, clinical scientists and biomedical scientists who are studying for higher qualifi cations to pursue a career in clinical biochemistry and metabolic medicine. In this edition, the number of clinical cases has been increased and these have been integrated into the text rather than collected at the end of each chapter. Clinical Biochemistry Lecture Notes

Th e order of chapters has been kept the same but we have taken the opportunity to update the material and to try to present it more clearly. Th e MCQs that featured at the end of the last edition have been gathered on-line and a detailed commentary provided on the reasons for the ‘true’ and ‘false’ answers to each question. An on-line resource also collects together the key points for each chapter. As with previous editions, we are indebted to our colleagues for contributing to this latest revision. We would particularly like to thank Maria Squires, Mike Crane, Neil Syme and Neil Squires for reading and commenting on some of the chapters in this new edition. Dr Allan Deacon kindly helped with his views on the investigation of porphyria. We would also like to express our thanks to the staff at Wiley for their continued interest and support towards this title since its appearance in 1975.

Introduction – Clinical Biochemistry Lecture Notes

Biochemical tests are crucial to modern medicine. Most biochemical tests are carried out on blood using plasma or serum, but urine, cerebrospinal fl uid (CSF), faeces, kidney stones, pleural fl uid, etc. are sometimes required. Plasma is obtained by collecting blood into an anticoagulant and separating the fl uid, plasma phase from the blood cells by centrifugation. Serum is the corresponding fl uid phase when blood is allowed to clot. For many (but not all) biochemical tests on blood, it makes little diff erence whether plasma or serum is used. Th ere are many hundreds of tests available in clinical biochemistry but a core of common tests makes up the majority of tests requested in clinical biochemistry.Clinical Biochemistry Lecture Notes

These core tests are typically available over a 24 h period. Tests are sometimes brought together in profi les, especially when a group of tests provides better understanding of a problem than a single test (e.g. the liver function test profi le). Many of the other more specialist tests are restricted to larger laboratories or specialist centres off ering a national or regional service. In dealing with the large number of routine test requests, the modern clinical biochemistry laboratory depends heavily on automated instrumentation linked to a laboratory computing system. Test results are assigned to electronic patient fi les that allow maintenance of a cumulative patient record. Increasingly, test requests can be electronically booked at the ward, clinic or in General Practice via a terminal linked to the main laboratory computer. Equally, the test results can be displayed on computer screens at distant locations, even negating the need for issuing printed reports. In this fi rst chapter, we set out some of the principles of requesting tests and of the interpretation of results. Th e eff ects of analytical errors and of physiological factors, as well as of disease, on test results are stressed. Biochemical testing in diff erential diagnosis and in screening is discussed.

About the Author

Peter Rae is Consultant Clinical Biochemist at the Royal Infirmary of Edinburgh, and Honorary Senior Lecturer, University of Edinburgh, UK.

Mike Crane is Consultant Clinical Scientist at the Royal Infirmary of Edinburgh and Royal Hospital for Sick Children, and Honorary Lecturer, University of Edinburgh, UK.

Rebecca Pattenden is Consultant Clinical Scientist at Western General Hospital, Edinburgh, UK.

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